Linear low-dose extrapolation for noncancer health effects is the exception, not the rule
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چکیده
منابع مشابه
Linear low-dose extrapolation for noncancer health effects is the exception, not the rule
The nature of the exposure-response relationship has a profound influence on risk analyses. Several arguments have been proffered as to why all exposure-response relationships for both cancer and noncarcinogenic endpoints should be assumed to be linear at low doses. We focused on three arguments that have been put forth for noncarcinogens. First, the general "additivity-to-background" argument ...
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A 140 volume 117 | number 4 | April 2009 • Environmental Health Perspectives PAH Exposure doi:10.1289/ehp.0800445 We were very interested to read the article by Choi et al. (2008). The difference between maternal exposure and our own data on actual concentrations of poly cyclic aromatic hydro carbons (PAHs) in the human male fetal liver (Fowler et al. 2008) was striking. Eight of the PAH exposu...
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Inevitable human exposure to ionizing radiation from man-made sources has been increased with the proceeding of human civilization and consequently public concerns focus on the possible risk to human health. Moreover, Fukushima nuclear power plant accidents after the 2011 East-Japan earthquake and tsunami has brought the great fear and anxiety for the exposure of radiation at low levels, even m...
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قاعده مقتضی و مانع در متون فقهی کم و بیش مستند احکام قرار گرفته و مورد مناقشه فقهاء و اصولیین می باشد و مشهور معتقند مقتضی و مانع، قاعده نیست بلکه یکی از مسائل ذیل استصحاب است لذا نگارنده بر آن شد تا پیرامون این قاعده پژوهش جامعی انجام دهد. به عقیده ما مقتضی دارای حیثیت مستقلی است و هر گاه می گوییم مقتضی احراز شد یعنی با ماهیت مستقل خودش محرز گشته و قطعا اقتضاء خود را خواهد داشت مانند نکاح که ...
15 صفحه اولOn the Linear Extrapolation to Low Doses
While radiobiological data are conveniently fitted by a linear quadratic formula to data of limited dynamic range at doses typically exceeding 1 Gy, they are extrapolated linearly to doses below a milligray for the evaluation of low dose RBEs. However a single relativistic electron passing through a cell nucleus deposits a “dose” there in the neighborhood of a milligray. The validity of the lin...
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ژورنال
عنوان ژورنال: Critical Reviews in Toxicology
سال: 2011
ISSN: 1040-8444,1547-6898
DOI: 10.3109/10408444.2010.536524